§2.2.8 · Chemicals › Psychedelics
2C-I
2,5-Dimethoxy-4-iodophenethylamine
Also known as 2ci · Smiles
Acute: Moderate riskDependency: Lower risk
Images
Quick reference
Routes
Oral
Form
Pill
Duration
Onset
1 Hour
Total duration
8 Hours
Experience
Primary effects
- Mild mental stimulation with a comfortable feeling, even in warm conditions.
- A light sheen or strengthening on vision, without definable open or closed-eye visuals.
- Enhanced sensual and tactile body warmth, with a dreamy mood and heightened concentration at times.
Peak character
- A smooth, unexciting, and stable psychedelic headiness with a tactile, clammy physical sensation.
- Rationality is fully maintained, with a general vibe of comfort and pleasantness.
Negatives / side effects
- Unpleasant taste if taken orally in pill form.
- Risk of uncomfortable body load being multiplied in hot conditions.
Aftereffects / comedown
- A gentle slide down in effects, leaving a warm and sensual afterglow with enhanced coloration.
- A soft landing of head and body high, leading to normal feelings the following morning after a good night's sleep.
Reference dosage
Reference ranges from third-party harm-reduction databases. Individual response varies enormously — start lower than you think.
Any route
| threshold | 2mg+ |
| light | 5mg+ |
| common | 10mg+ |
| strong | 20mg+ |
Reagent testing
Expected reactions
| Marquis | Yellow → green |
| Mecke | Blue/green |
| Froehde | Orange → red/brown |
Adulterant detection: Iodine-substituted compound; follow 2C-x protocol.
Standard 2C-x reagent battery applies.
Source
Reference fields and narrative for 2C-I extracted from The Drug Users Bible by Dominic Milton Trott (MxZero Publishing, 2022).
drugusersbible.comHarm reduction notice
This platform provides educational and harm-reduction information adapted from public reference material. It does not endorse, encourage, or facilitate drug use. It is not medical advice. If you or someone near you may be in a medical emergency, contact local emergency services immediately.