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§2.2.9 · ChemicalsPsychedelics

4-ACO-DMT

O-Acetylpsilocin

Also known as 4-Acetoxy-DMT · Psilacetin

Acute: Moderate riskDependency: Lower risk

Images

Quick reference

Routes
Oral
Form
Powder
Shulgin rating
++*

Duration

Onset
2 Hours
Total duration
8 Hours

Experience

Primary effects

  • Induces a psychedelic headspace with enhanced colors and drifting focus, similar to psilocybin.
  • Causes visual distortions such as diffraction, slight morphing, tracers, and over-currents.
  • Results in pupil dilation and can feel surprisingly potent even at low doses.

Peak character

  • Headspace can be strong and immersive, leading to a profound, restful, or even sleep-inducing state.

Negatives / side effects

  • Can lead to overwhelming '++++' experiences at doses under 20mg; caution and standard safety measures are essential.
  • Combining with fatigue or hangover can amplify the need for sleep, potentially cutting short the experience.

Aftereffects / comedown

  • Short duration, leading to a quick return to baseline after the peak effects subside.
  • Can induce deep sleep or dozing during the experience, followed by feeling well-awake afterwards.

Reference dosage

Reference ranges from third-party harm-reduction databases. Individual response varies enormously — start lower than you think.

Any route
threshold2.5mg+
light3mg+
common8mg+
strong25mg+

Reagent testing

Recommended reagents
Expected reactions
EhrlichPurple/violet (strong)
HofmannBlue → green
MeckeBlue → green

Adulterant detection: Ehrlich is highly reliable for this tryptamine. Absence of purple is a clear red flag.

Synthetic psilocybin analogue — one of the cleanest Ehrlich reactions in the tryptamine family.

Source

Reference fields and narrative for 4-ACO-DMT extracted from The Drug Users Bible by Dominic Milton Trott (MxZero Publishing, 2022).

drugusersbible.com

Harm reduction notice

This platform provides educational and harm-reduction information adapted from public reference material. It does not endorse, encourage, or facilitate drug use. It is not medical advice. If you or someone near you may be in a medical emergency, contact local emergency services immediately.