All substances
§2.5.8 · ChemicalsIntoxicating Depressants

Oxycodone

Oxycodone

Also known as Oxy · Oxynorm · Oxycotten · Ocycontin · Hillbilly · Hillbilly Heroin

Acute: Extreme riskDependency: Extreme risk Test for fentanyl

Images

Quick reference

Routes
Oral

Duration

Onset
30 Minutes
Total duration
6 Hours

Experience

Primary effects

  • Oxycodone is an opioid medication used to treat moderate to severe pain, providing a gentle bubble of warm tranquility and a slight sense of numbness.
  • It induces a mellow-headedness, reduces anxiety, and promotes relaxation.

Peak character

  • The peak is a pleasant, gentle experience, described as a 'bubble of warm tranquility' with an undeniable uplift, but not euphoric.

Negatives / side effects

  • High risk of overdose and addiction; it ranked #1 in drug overdose deaths mentioning specific drugs in 2011.
  • Do not mix with alcohol, other medicines, or grapefruit (a potentiator).
  • Snorting greatly increases dose sensitivity and risk; a 40mg pill is dangerous for non-tolerant users.
  • Potential side effects include dizziness and nausea, particularly as the effects wear off.

Aftereffects / comedown

  • As effects wane, a comfortable zone transitions to potential dizziness and mild queasiness.
  • The comedown can involve feeling exhausted and 'down about everything'.

Reference dosage

Reference ranges from third-party harm-reduction databases. Individual response varies enormously — start lower than you think.

oral
light2.5mg+
common5mg+
strong10mg+

Reagent testing

Recommended reagents
Expected reactions
MarquisYellow → orange/brown (less dark than morphine/heroin)
MeckeYellow → green/blue
FroehdeYellow → orange/brown
MandelinBrown/black

Adulterant detection: CRITICAL: Counterfeit oxycodone pills (fake 'M30' tablets) are one of the primary vectors for fentanyl poisoning deaths. Fentanyl strip testing is a priority.

Oxycodone has a distinct Mecke reaction (less intensely blue than morphine/heroin) which can help distinguish it, but fentanyl strips are the critical safety test for any pressed pill.

Source

Reference fields and narrative for Oxycodone extracted from The Drug Users Bible by Dominic Milton Trott (MxZero Publishing, 2022).

drugusersbible.com

Harm reduction notice

This platform provides educational and harm-reduction information adapted from public reference material. It does not endorse, encourage, or facilitate drug use. It is not medical advice. If you or someone near you may be in a medical emergency, contact local emergency services immediately.