§2.2.21 · Chemicals › Psychedelics

TMA

3,4,5-Trimethoxyamphetamine

Also known as TMA

Acute: Moderate riskDependency: Lower risk

Images

Quick reference

Routes

Oral

Form

Powder

Shulgin rating

Duration

Onset

90 Minutes

Total duration

8 Hours

Experience

Primary effects

Mild headiness, comfortable body warmth, and gentle tactility often characterize the initial effects.
Potential for sexual enhancement and a dreamy, drifty head space may be present.

Peak character

Characterized by a mild psychedelic aura without significant visuals, allowing for normal functioning.
The experience is described as a gentle pleasure, comfortable and content, rather than an intense 'high'.

Negatives / side effects

Initial coldness, especially in extremities, and fatigue can be experienced.
There is a risk of a vague headache and general 'jaded' feeling as effects begin to fade.
Caution is advised, particularly for individuals with pre-existing heart conditions or low body temperature, as high doses of TMA-2 have shown bradycardia and hypothermia in animal studies.

Aftereffects / comedown

Effects slowly fade over several hours, leaving a 'zoned out headiness' and lethargy.
A short nap might not energize, but a reasonable night's sleep is generally reported, leading to a positive and healthy awakening.

Reagent testing

Recommended reagents

Marquis Mecke Liebermann

Expected reactions

Marquis	Yellow/orange → reddish
Mecke	Blue/green
Liebermann	Orange

Adulterant detection: Trimethoxyamphetamine — phenethylamine. Rapid black Marquis indicates a different amphetamine adulterant.

MAOI activity — dangerous drug interactions. Testing important; interactions cannot be tested with colorimetric reagents.

Source

Reference fields and narrative for TMA extracted from The Drug Users Bible by Dominic Milton Trott (MxZero Publishing, 2022).

drugusersbible.com

Harm reduction notice

This platform provides educational and harm-reduction information adapted from public reference material. It does not endorse, encourage, or facilitate drug use. It is not medical advice. If you or someone near you may be in a medical emergency, contact local emergency services immediately.